It has been awhile since I last posted anything, so I thought I would bring everyone up to date on what’s happening.

As I said in a previous blog, I have a 17p deletion, which is the worst one to have in the game of SLL/CLL. Life span is not usually to good for those with this deletion. Somewhere around 32 months, where as I have had this cancer going on 52 months so far. I am still on watch and wait, and am real happy about that, as no current chemotherapy works very well on this deletion. Sounds bad, but all of this time, I have felt quite healthy, occasionally having bouts with shortness of breath, excessive bleeding, but really nothing that stopped me from living my life as I always have.

Many have been working on finding something that will work on this 17p, and as I have been reading, I have been seeing that two new therapies are being tested, and are in their third phase of tests. PCI-32765 and  CAL-101. It looks as if they are targeted drugs, and are in pill form. They have not been approved yet, but there is much promise in them, and hopefully will be approved for human use soon. The PCI-32765 has shown to be quite promising for those of us with the 17p deletion.

The following is from the National Cancer Institute, April 2, 2012. Investigational targeted drug induces responses in aggressive lymphomas

Preliminary results from clinical trials in a subtype of lymphoma show that for a number of patients whose disease was not cured by other treatments, the drug ibrutinib (formly called PCI-32765) can provide significant anti-cancer responses with  modest side effects.

Lymphomas are the fifth most common form of cancer. They are caused by an abnormal proliferation of white blood cells, can occur at any age,  and are often marked by lymph nodes that are larger than normal, fever, and weight loss. Diffuse large B-cell lymphomas (DLBCL), which were studied in this trial, are aggressive cancers that grow rapidly and represent 30 percent to 40 percent of newly diagnosed lymphomas. DLBCL originates from B cells, which play a crucial role in the body’s immune response.

Based on this molecular research, investigators chose to use the drug ibrutinib (formerly PCI-32765), a potent inhibitor of BTK, in their clinical trials. Ibrutinib is an oral, highly specific and irreversible inhibitor of the BTK enzyme.

Participants in these studies were given ibrutinib as a pill at a fixed dose of 560 milligrams daily until the disease progresses. Ibrutinib  induced multiple responses including some complete remissions in ABC        lymphomas. Remissions were also observed in patients with non-ABC DLBCL, suggesting a broader role for the B-cell receptor pathway in this type of lymphoma. A final analysis will provide additional insights into the safety and efficacy of ibrutinib in the treatment of DLBCL.

I know that the above may be uninteresting reading to some of you, but thank you for reading it anyway. There are some who read this blog that are going through this fight right now, and I hope that if they have not seen this information yet, reading this blog with lift their spirit. It is my hope that these new therapies will be effective for those whose current therapies just will not work.

For me currently, I have been feeling real good since my last visit to the doctor, so good, that I sometimes wonder if they made a mistake in my diagnosis. Wouldn’t that be nice.  Anyway I have been doing really good, I have no pains, spleen, stomach, or neck, and no night sweats. It seems that some of the tumors that I had in my neck have gotten really small, and some of the bumps on my back are gone.

I am eating more than I had been, and I work around the place more each day, because I am not losing my breath at all, and I don’t get tired as easily as I did before. At my last visit, my doctor was surprised that the aggressiveness of my cancer looked to  have stopped. He did not know why, but was pleased, as was I.

Again I have to thank all those who have been praying for me, and I have been thanking the Great Physician. I am reminded of one of my motorcycle club members, that was told he had throat cancer, stage 4, and had five months to live. He told the doctor that he was going to talk with the Great Physician, and the doctors reply was, if you change doctors, you will not be covered by your insurance here any longer. (That was two years ago, and his last tests showed he no longer had throat cancer).

So with this dear doctor in mind, I am talking about Jesus Christ, the one who said, “Come to Me, all you who labor and are heavy laden, and I will give you rest. Take My yoke upon you and learn from Me, for I am gentle and lowly in heart, and you will find rest for your souls. For MY yoke is easy and My burden is light.”

I will be seeing my Oncologist on April 26th, and I have no idea what my blood results will be, but one thing I am sure of. It is God who knows the number of my days, and until that number is up, I will be here enjoying and marveling at all He has created.

But what if I seek to be made right with God through faith in Jesus Christ, and find out that I am still a sinner? has Christ led me into sin? Of course not! Rather I make myself guilty if I rebuild the old system I already tore down. For when I tried to keep the law, I realized I could never earn God’s approval. so I died to the law, so that I may live for God. I have been crucified with Christ. So I live my life in this earthly body by trusting in the Son of God. I am not one of those that treats the grace of God as meaningless. For if I could be saved by keeping the law, then there was no need for Christ to die.      Galatians 2

So if you chose to put your faith in Christ, do not at a later time try to become perfect, by your own human effort.

http://justin.tv/alphamin – great live Sunday service at 11:00 am. If you don’t like mountain music, then tune in around 11:20 am. I guarantee that you have not ever heard, what you will hear there.

God bless, and keep the faith

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